曹秀芳,博士,副教授,碩士生導師。主要研究方向:新雜環農藥、醫藥的設計合成;天然活性物質提取及結構衍生化。曾主持國家基金、湖北省重點研發計劃課題、湖北省面上項目、校優秀人才培育項目、校重大培育項目、學科交叉基金及多項企業委托橫向項目。在期刊Journal of Agricultural and Food Chemistry、European Journal of Medicinal Chemistry等雜志上以第一或通訊作者發表SCI論文40餘篇,獲批軟件著作權1部,授權發明專利3項,獲湖北省科技發明獎二等獎一項。主講有機化學及相關實驗課程,作為課程負責人獲批省一流課程一門,主編“十三五”規劃教材《有機化學實驗》,副主編“十三五”規劃教材《基礎有機化學實驗》,主持省校級各類教改課題多項,獲77779193永利官网教學質量優秀獎一等獎、二等獎,校“獅山碩彥計劃”教學能手。指導研究生獲評優秀學位論文,指導大學生國創項目三項,省創一項,指導學生獲湖北省大學生化學實驗技能大賽一等獎等榮譽。
聯系方式:E-mail:caoxiufang@mail.hzau.edu.cn
主持科研項目:
1. 湖北省重點研發計劃課題:靶向植物病毒關鍵蛋白TMV-CP 的藥物發掘及應用,2023-2025;
2. 湖北省自然科學基金:靶向植物病原NLP蛋白抑制劑的設計優化及作用機制,2022-2024;
3. 橫向課題:福白菊中FBJ-2的分離提取,2023;
4. 橫向課題:阿爾茨海默病動物模型相關研究之煙草生物堿提取分析,2018-2023;
5. 校重大培育項目:天然組分的農藥化學生物學研究,2016-2018;
6. 校優秀人才培育項目:靶向ACCase酶的雜環内酰胺衍生物的先導優化及作用機制研究,2015-2017;
7. 國家自然科學基金:植物精油導向的手性菊酯類似物的合成及殺蟲活性研究,2012-2014。
代表性論文與專利:
1. Zilin Gao, Xiufang Cao*, et al. Structural diversity-guided optimization of carbazole derivatives as potential cytotoxic agents, Frontiers in Chemistry, 2023, 11, 1104868.
2. Zilin Gao, Xiufang Cao*, et al. Highly efficient construction of multi-substituted aminopyrazoles derivatives via iodine-mediated three-components reaction as potential anticancer agents, Green Chemistry Letters and Reviews, 2023, 16(1), 2264324.
3. Yahao Du, Hang Sheng, Feifei Cao, Jilei Shi*, Xiufang Cao*, Yuguo Guo*, et al. Chemically Convert Residual Lithium to a Composite Coating Layer to Enhance Rate Capability and Stability of Single-Crystalline Ni-Rich Cathodes, Nano Energy 2022, 94, 106901.
4. Xuyang Wei, Jinwen Yang, Feifei Cao, Jiangjiang Gu*, Xiufang Cao*, Recent advances in room temperature phosphorescent carbon dots: preparation, mechanism, and applications, J. Mater. Chem. C, 2021, 9, 4425-4443.
5. Daye Huang, Shuangshuang Wang, Di Song, Xiufang Cao*, et al. Discovery of γ-lactam alkaloids derivatives as potential fungicidal agents targeting steroid biosynthesis, J. Agric. Food Chem., 2020, 68(49), 14438-14451.
6. Di Song, Xiufang Cao*, et al. Discovery of γ-lactam derivatives containing 1,3-benzodioxole unit as potential anti-phytopathogenic fungus agents, Bioorganic & Medicinal Chemistry Letters, 2020, 30, 126826.
7. Shuangshuang Wang, Xiufang Cao*, et al. Amino acid-oriented poly-substituted heterocyclic tetramic acid derivatives as potential antifungal agents, European Journal of Medicinal Chemistry, 2019, 179, 567-575.
8. Shuangshuang Wang, Longzhu Bao, Xiufang Cao*, Heterocyclic lactam derivatives containing piperonyl moiety as potential antifungal agents, Bioorganic & Medicinal Chemistry Letters, 2019, 29, 126661.
9. Xiufang Cao, Wenda Wang, et al. Asymmetric synthesis of novel triazole derivatives and their in vitro antiviral activity and mechanism of Action, European Journal of Medicinal Chemistry, 2017, 139, 718-725.
10. 曹秀芳,王文達等. 煙草提取物用于桔小實蠅殺蟲劑的用途. 授權專利: ZL201711249501.3, 2019.
11. 曹秀芳,陳長水等.一種具有抗腫瘤活性的化合物及其應用. 授權專利: ZL201610023375.9, 2017.
12. 曹秀芳,陳長水等.一種拟除蟲菊酯化合物及其制備方法與應用.授權專利: ZL201310195522.7, 2015.
13. 曹秀芳,郭立榮,萬亞飛. 一種苯并噻唑衍生物及其應用,發明專利,2023114391160,2023。